Phenotypes Associated with This Genotype

Genotype
MGI:5529327

• Allelic Composition: Clec4f^tm1Ymed/Clec4f^tm1Ymed
• Genetic Background: B6.129S7-Clec4f^tm1Ymed

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:203199 )

N • mice exhibit normal susceptibility to L. monocytogenes infection

abnormal macrophage cytokine production ( J:203199 )

• Kupffer cells stimulated with alpha-GalCer produce less IFN-gamma compared with wild-type mice

• however, stimulated mice produce normal amounts of IL4

decreased interferon-gamma secretion ( J:203199 )

• from Kupffer cells stimulated with alpha-GalCer

• however, suppression using a blocking antibody against Cd1d1 is normal

hematopoietic system

abnormal macrophage cytokine production ( J:203199 )

• Kupffer cells stimulated with alpha-GalCer produce less IFN-gamma compared with wild-type mice

• however, stimulated mice produce normal amounts of IL4