Phenotypes Associated with This Genotype

Genotype
MGI:5528811

• Allelic Composition: Tg(Mbp-Cadm4*)#Pele/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:199632 )

• tend to stagger

• fall more rapidly from a rotarod

hindlimb paralysis ( J:199632 )

nervous system

abnormal myelin sheath morphology ( J:199632 )

• display a range of abnormalities including tomacula, comma shaped myelin outfolds and redundant myelin profiles

• in some cases the tomacula are accompanied with myelin degeneration around the axon and axonal displacement

• redundant outfoldings are present in the Schwann cell cytoplasm, between the myelin sheath and axon, and are located near paranodes and Schmidt-Lanterman incisures

• at 2 weeks of age detachment of the myelin sheath from the axon at the inner mesaxon and the presence of multiple inner myelin lips are seen

• abnormalities are detected during the first postnatal week

abnormal paranode morphology ( J:199632 )

• abnormal splitting of the paranodal loops

abnormal myelination ( J:199632 )

• at P1 and P3 fewer axons display myelin profiles compared to controls

hypermyelination ( J:199632 )

• 81% of myelinated axons display at least 1 focal site of hypermyelination

decreased nerve conduction velocity ( J:199632 )