Tg(Mbp-Cadm4*)#Pele
Transgene Detail

Summary

• Symbol: Tg(Mbp-Cadm4*)#Pele
• Name: transgene insertion, Elior Peles
• MGI ID: MGI:5528809
• Synonyms: Tg(mbp-Cadm4dCT)
• Transgene: Tg(Mbp-Cadm4*)#Pele Location: unknown
• Alliance: Tg(Mbp-Cadm4*)#Pele page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The myelin basic protein promoter drives expression of a myc-tagged mutant Cadm4 transcript lacking the entire cytoplasmic domain. This functions as a dominant negative mutation. Western blot analysis demonstrated strong expression in the sciatic nerve. (J:199632)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:199632 Golan N, et al., Genetic deletion of Cadm4 results in myelin abnormalities resembling charcot-marie-tooth neuropathy. J Neurosci. 2013 Jul 3;33(27):10950-61
• All: 2 reference(s)