Phenotypes Associated with This Genotype

Genotype
MGI:5514355

• Allelic Composition: Fktn^tm3.1Ttd/Fktn^tm3.1Ttd; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle fiber morphology ( J:198535 )

• exercised mice exhibit increased membrane-impermeable Evans blue dye uptake compared with cells from control mice

centrally nucleated skeletal muscle fibers ( J:198535 )

• at 16 weeks, increasing with age

skeletal muscle necrosis ( J:198535 )

• at 16 weeks

dystrophic muscle ( J:198535 )

• at 16 weeks with myonecrosis and central nucleation

homeostasis/metabolism

increased circulating creatine kinase level ( J:198535 )

• at 16 weeks

• after forced exercise

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
muscular dystrophy-dystroglycanopathy type B1		DOID:0050588	OMIM:613155	J:198535