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Phenotypes Associated with This Genotype
Genotype
MGI:5467385
Allelic
Composition		 Pycardtm1Ayaz/Pycardtm1Ayaz
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (42 available)
Pycardtm1Ayaz mutation (0 available); any Pycard mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 alpha secretion ( J:191239 )
• from tumors induced by DMBA
decreased interleukin-1 beta secretion ( J:191239 )
• from tumors induced by DMBA
decreased interleukin-6 secretion ( J:191239 )
• from tumors induced by DMBA
decreased tumor necrosis factor secretion ( J:191239 )
• from tumors induced by DMBA

neoplasm
decreased incidence of tumors by chemical induction ( J:191239 )
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit fewer tumors with a later onset compared with type mice

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:191239 )
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit fewer tumors with a later onset compared with type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory