Phenotypes Associated with This Genotype

Genotype
MGI:5449076

• Allelic Composition: Tg(TNF)3647Gkl/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

impaired osteoblast differentiation ( J:190204 )

• from isolated bone marrow-derived stromal cells

autoimmune arthritis ( J:190204 )

• at 2 to 3 months

osteoporosis ( J:190204 )

• at 4 months

abnormal bone ossification ( J:190204 )

• reduced bone formation rate

abnormal bone mineralization ( J:190204 )

• reduced mineral apposition rate

immune system

autoimmune arthritis ( J:190204 )

• at 2 to 3 months

cellular

impaired osteoblast differentiation ( J:190204 )

• from isolated bone marrow-derived stromal cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
rheumatoid arthritis		DOID:7148	OMIM:180300	J:190204