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Transgene Detail
Symbol: Tg(TNF)3647Gkl
Name: transgene insertion 3647, George Kollias
MGI ID: MGI:4818266
Synonyms: Tg3647
Transgene: Tg(TNF)3647Gkl  Location: unknown  
Alliance: Tg(TNF)3647Gkl page
Strain of Origin:  (CBA x C57BL/6)
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(TNF)3647Gkl expresses 1 gene
Mutation detailsThe transgene comprises the human tumor necrosis factor gene with its 3' UTR, polyadenylation signal and flanking sequence replaced by those of the human hemoglobin beta (HBB) gene. This modification interferes with posttranscriptional regulation of TNF expression, altering expression levels and timing, but apparently not its tissue specificity. (J:92576)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:92576 Keffer J, et al., Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 1991 Dec;10(13):4025-31
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory