Phenotypes Associated with This Genotype

Genotype
MGI:5441199

• Allelic Composition: Aim2^tm1Ktak/Aim2^tm1Ktak
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:188013 )

• in mice infected with Mycobacterium tuberculosis

immune system

decreased circulating interleukin-18 level ( J:188013 )

• in mice infected with M. tuberculosis

decreased interferon-gamma secretion ( J:188013 )

• in CD4+ T cells from M. tuberculosis-infected mice stimulated with a mycobacterial-specific antigen

decreased interleukin-1 beta secretion ( J:188013 )

• in cultures of peritoneal macrophages exposed to poly(dA:dT)

• in the bronchoalveolar lavage fluid of mice infected with M. tuberculosis

• from macrophages from M. tuberculosis-infected mice

• however, ATP-induced secretion is normal

decreased interleukin-18 secretion ( J:188013 )

• in cultures of peritoneal macrophages exposed to poly(dA:dT)

• from macrophages from M. tuberculosis-infected mice

increased susceptibility to bacterial infection ( J:188013 )

• mice infected with Mycobacterium tuberculosis exhibit increased lung and liver colony-forming unit titers, decreased IL1B secretion in the bronchoalveolar lavage fluid, decreased IL1B and IL18 secretion from macrophage, decreased circulating IL18 levels and increased mortality compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:188013 )

• in mice infected with Mycobacterium tuberculosis

homeostasis/metabolism

decreased circulating interleukin-18 level ( J:188013 )

• in mice infected with M. tuberculosis