Phenotypes Associated with This Genotype

Genotype
MGI:5437688

• Allelic Composition: Tg(SERPINC1-SV40)A1Pbr/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:101541 )

• mutants do not survive for more than 10 months and most often die around 8 months of age

neoplasm

increased hepatocellular carcinoma incidence ( J:101541 )

• all mice develop hepatocellular carcinoma at 8 months of age

• tumor development begins with the appearance of small, numerous and well-delimited tumoral nodules by 4 months of age, development into hepatocellular adenomas at 6 months of age, and finally complete disorganization of the hepatic architecture with numerous foci of polyadenoid, glanduliform and trabecular hepatocarcinoma

increased metastatic potential ( J:101541 )

• lung metastasis is observed in some mutants

liver/biliary system

abnormal liver morphology ( J:101541 )

• mutants exhibit anisocaryosis and abnormal mitosis in the liver at 2 months of age

increased hepatocellular carcinoma incidence ( J:101541 )

• all mice develop hepatocellular carcinoma at 8 months of age

• tumor development begins with the appearance of small, numerous and well-delimited tumoral nodules by 4 months of age, development into hepatocellular adenomas at 6 months of age, and finally complete disorganization of the hepatic architecture with numerous foci of polyadenoid, glanduliform and trabecular hepatocarcinoma

abnormal hepatocyte physiology ( J:101541 )

• hepatic cytolysis occurs as early as 3-4 weeks of age and reaches a first peak at 7 weeks, before the formation of nodules, then a second increase in cytolysis is seen between 6-8 months

cellular

abnormal cell nucleus morphology ( J:101541 )

• anisocaryosis in the liver at 2 months of age

hematopoietic system

anisocytosis ( J:101541 )

• seen at 2 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:101541