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Phenotypes Associated with This Genotype
Genotype
MGI:5430234
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1Tyj
Tg(Prrx1-FUS/DDIT3)1Mete/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-FUS/DDIT3)1Mete mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sarcoma incidence ( J:184491 )
• predominantly in the appendicular skeleton
increased liposarcoma incidence ( J:184491 )
• mice develop myxoid round cell liposarcoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
myxoid liposarcoma DOID:5363 OMIM:613488
 J:184491

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory