Analysis Tools
mortality/aging
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• early
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homeostasis/metabolism
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• at 10 weeks after a 4 hour fast
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• increased random plasma glucose by 10 weeks
• at 10 weeks, after a 24 hour fast and 6 hour refeed
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• increased random plasma insulin by 10 weeks
• at 10 weeks, after a 4 hour fast or 24 hour fast and 6 hour refeed
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• at 10 weeks, under fasted conditions
• at 12 weeks
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• at 10 weeks, after a 24 hour fast and 6 hour refeed
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• mice exhibit decreased plasma glycerol under random or fasted conditions or following CL 316243 stimulation compared with wild-type mice
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• after a 24 hour fast and 6 hour refeed
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• at 10 weeks, under fasted conditions
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• at 10 weeks, after a 24 hour fast and 6 hour refeed
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• in mouse embryonic fibroblasts and stromal vascular cells induced to differentiate into adipocytes
• in unstimulated or CL 316243-stimulated mice
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• epididymal and subcutaneous white adipose tissue exhibit changes in lipid metabolism, with decreased levels of triacylglyceride and increased levels of other lipid classes, including cholesterol ester, nonesterified free fatty acid, diacylglyceride , free cholesterol and phospholipids
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adipose tissue
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• mouse embryonic fibroblasts and stromal vascular cells induced to differentiate into adipocytes fail to maintain and terminate adipocyte differentiation unlike wild-type cells
• however, ER stress-related apoptosis is not responsible for the aborted adipogenesis and lipase inhibitors rescue adipogenesis
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• massive loss of epididymal white adipose tissue
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• at 12 weeks
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• at 12 weeks
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• at 12 weeks
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• residual epididymal white adipose tissue has decreased levels of triacylglyceride but increased levels of other lipid classes, including cholesterol ester, nonesterified free fatty acid, diacylglyceride, free cholesterol and phospholipids
• visceral white adipose tissues show altered elongation and desaturation in total fatty acid compositions; decrease in palmitic16:0 and increase in oleic18:1n9, decrease in alpha-linolenic18:3n3, gamma-linolenic 18:3n6, and increase in DHA22:6n3
• epididymal white adipose tissue show changes in molecular species of glycerolipids, with most showing relative decreases in short or very long fatty acyl chains
• residual subcutaneous white adipose tissues are not browning but show altered lipid metabolism, with decreased levels of triacylglyceride and increased levels of other lipid classes, including cholesterol ester, nonesterified free fatty acid, diacylglyceride , free cholesterol and phospholipids
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• at 12 weeks
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• massive loss of epididymal white adipose tissue
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• lipid droplets lose their multilobular structure
• fewer in number with small droplets interspersed with giant ones
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• inferred from reduced DNA content
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• residual epididymal white adipose tissue shows induction of brown adipose tissue gene signature, indicating browning of white adipose tissue
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cellular
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• mouse embryonic fibroblasts and stromal vascular cells induced to differentiate into adipocytes fail to maintain and terminate adipocyte differentiation unlike wild-type cells
• however, ER stress-related apoptosis is not responsible for the aborted adipogenesis and lipase inhibitors rescue adipogenesis
|
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• mouse embryonic fibroblast-derived adipocytes exhibit increased aerobic and anaerobic respiration compared with wild-type cells
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• increased
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behavior/neurological
polyphagia
(
J:183701
)
|
• in male mice
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cardiovascular system
digestive/alimentary system
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• longer than in control mice
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growth/size/body
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• during the first 3 weeks of life
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• during the first 3 weeks of life
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hematopoietic system
immune system
integument
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• at 12 weeks
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liver/biliary system
renal/urinary system
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital generalized lipodystrophy type 2 | DOID:0111136 |
OMIM:269700 |
J:211142 | |
