Phenotypes Associated with This Genotype

Genotype
MGI:5316864

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs; Tacstd2^tm1Lsm/Tacstd2^tm1Lsm
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased keratinocyte migration ( J:182647 )

• in a wound healing assay, immortalized keratinocytes exhibit increased migration compared with control cells

• however, over-expression of Tacstd2 reduces migration

increased keratinocyte proliferation ( J:182647 )

• of immortalized keratinocytes in culture

• however, over-expression of Tacstd2 reduces proliferation

abnormal skin development ( J:182647 )

• primary keratinocytes transfected with an H-Ras 12V-expressing lentivirus and transferred into nude mice exhibit increased epithelial to mesenchyme transition compared with control cells

increased skin squamous cell carcinoma incidence ( J:182647 )

• 3 of 5 sarcomatoid carcinomas that develop in mice treated with DMBA-TPA have squamous cell histology

neoplasm

increased carcinoma incidence ( J:182647 )

• 6 of 24 mice treated with DMBA-TPA develop carcinomas (sarcomtoid and poorly differentiated high grade) unlike control mice

• 5 of 6 tumors that develop in mice treated with DMBA-TPA are sarcomatoid carcinomas

• 1 of 6 tumors that develop in mice treated with DMBA-TPA are poorly differentiated high grade carcinomas

increased skin squamous cell carcinoma incidence ( J:182647 )

• 3 of 5 sarcomatoid carcinomas that develop in mice treated with DMBA-TPA have squamous cell histology

increased spindle cell carcinoma incidence ( J:182647 )

• primary keratinocytes transfected with an H-Ras 12V-expressing lentivirus and transferred into nude mice form tumors with spindle cell histology and no squamous cell histology compared with control mice which form tumors with predominantly squamous cell histology and some spindle cell components

• 5 of 6 tumors in mice treated with DMBA-TPA are sarcomatoid carcinomas

homeostasis/metabolism

enhanced wound healing ( J:182647 )

• in a wound healing assay, immortalized keratinocytes exhibit increased migration compared with control cells

• however, over-expression of Tacstd2 reduces migration

cellular

increased keratinocyte migration ( J:182647 )

• in a wound healing assay, immortalized keratinocytes exhibit increased migration compared with control cells

• however, over-expression of Tacstd2 reduces migration

increased keratinocyte proliferation ( J:182647 )

• of immortalized keratinocytes in culture

• however, over-expression of Tacstd2 reduces proliferation