Tacstd2^tm1Lsm
Targeted Allele Detail

Summary

• Symbol: Tacstd2^tm1Lsm
• Name: tumor-associated calcium signal transducer 2; targeted mutation 1, Loren S Michel
• MGI ID: MGI:5316861
• Gene: Tacstd2 Location: Chr6:67511046-67512780 bp, - strand Genetic Position: Chr6, 30.88 cM, cytoband C1
• Alliance: Tacstd2^tm1Lsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182647
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neo cassette replaced the coding sequence. RT-PCR confirmed the absence of transcript expression. (J:182647)

Tumor Data

List all tumor models in MMHCdb carrying Tacstd2^tm1Lsm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tacstd2 Mutation: 16 strains or lines available

References

• Original: J:182647 Wang J, et al., Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma. Mol Cancer Res. 2011 Dec;9(12):1686-95
• All: 1 reference(s)