Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tacstd2tm1Lsm targeted mutation 1, Loren S Michel MGI:5316861 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal life expectancy
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| N |
• normal development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in a wound healing assay, immortalized keratinocytes exhibit increased migration compared with control cells
• however, over-expression of Tacstd2 reduces migration
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• of immortalized keratinocytes in culture
• however, over-expression of Tacstd2 reduces proliferation
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• primary keratinocytes transfected with an H-Ras 12V-expressing lentivirus and transferred into nude mice exhibit increased epithelial to mesenchyme transition compared with control cells
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• 3 of 5 sarcomatoid carcinomas that develop in mice treated with DMBA-TPA have squamous cell histology
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• 6 of 24 mice treated with DMBA-TPA develop carcinomas (sarcomtoid and poorly differentiated high grade) unlike control mice
• 5 of 6 tumors that develop in mice treated with DMBA-TPA are sarcomatoid carcinomas
• 1 of 6 tumors that develop in mice treated with DMBA-TPA are poorly differentiated high grade carcinomas
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• 3 of 5 sarcomatoid carcinomas that develop in mice treated with DMBA-TPA have squamous cell histology
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• primary keratinocytes transfected with an H-Ras 12V-expressing lentivirus and transferred into nude mice form tumors with spindle cell histology and no squamous cell histology compared with control mice which form tumors with predominantly squamous cell histology and some spindle cell components
• 5 of 6 tumors in mice treated with DMBA-TPA are sarcomatoid carcinomas
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• in a wound healing assay, immortalized keratinocytes exhibit increased migration compared with control cells
• however, over-expression of Tacstd2 reduces migration
|
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• in a wound healing assay, immortalized keratinocytes exhibit increased migration compared with control cells
• however, over-expression of Tacstd2 reduces migration
|
|
• of immortalized keratinocytes in culture
• however, over-expression of Tacstd2 reduces proliferation
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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