Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacstd2tm1Lsm mutation
(0 available);
any
Tacstd2 mutation
(16 available)
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mortality/aging
embryo
neoplasm
N |
• mice treated with DMBA-TPA exhibit normal tumorigenesis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Tacstd2tm1Lsm mutation
(0 available);
any
Tacstd2 mutation
(16 available)
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integument
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• in a wound healing assay, immortalized keratinocytes exhibit increased migration compared with control cells
• however, over-expression of Tacstd2 reduces migration
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• of immortalized keratinocytes in culture
• however, over-expression of Tacstd2 reduces proliferation
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• primary keratinocytes transfected with an H-Ras 12V-expressing lentivirus and transferred into nude mice exhibit increased epithelial to mesenchyme transition compared with control cells
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• 3 of 5 sarcomatoid carcinomas that develop in mice treated with DMBA-TPA have squamous cell histology
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neoplasm
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• 6 of 24 mice treated with DMBA-TPA develop carcinomas (sarcomtoid and poorly differentiated high grade) unlike control mice
• 5 of 6 tumors that develop in mice treated with DMBA-TPA are sarcomatoid carcinomas
• 1 of 6 tumors that develop in mice treated with DMBA-TPA are poorly differentiated high grade carcinomas
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• 3 of 5 sarcomatoid carcinomas that develop in mice treated with DMBA-TPA have squamous cell histology
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• primary keratinocytes transfected with an H-Ras 12V-expressing lentivirus and transferred into nude mice form tumors with spindle cell histology and no squamous cell histology compared with control mice which form tumors with predominantly squamous cell histology and some spindle cell components
• 5 of 6 tumors in mice treated with DMBA-TPA are sarcomatoid carcinomas
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homeostasis/metabolism
cellular
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• in a wound healing assay, immortalized keratinocytes exhibit increased migration compared with control cells
• however, over-expression of Tacstd2 reduces migration
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• of immortalized keratinocytes in culture
• however, over-expression of Tacstd2 reduces proliferation
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