Phenotypes Associated with This Genotype

Genotype
MGI:5308727

hm3

• Allelic Composition: Dcn^tm1Ioz/Dcn^tm1Ioz
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal cutaneous collagen fibril morphology ( J:91512 )

• increase in average fibril diameter and range of diameters

• larger fibrils often exhibit an irregular cross-sectional profile

thin dermal layer ( J:91512 )

decreased skin tensile strength ( J:91512 )

• at 2 months of age

skeleton

abnormal tendon morphology ( J:91512 )

• in the tail tendon collagen fibrils show a unimodal rather than bimodal frequency distribution resulting from a relative decrease in number of larger fibrils and a relative increase in number of smaller fibrils

• in the tail tendon the fibril size range and average diameter are increased

abnormal bone structure ( J:91512 )

• both average collagen fibril diameter and fibril size range are decreased

• collagen fibrils have irregular cross-sectional profiles

muscle

abnormal tendon morphology ( J:91512 )

• in the tail tendon collagen fibrils show a unimodal rather than bimodal frequency distribution resulting from a relative decrease in number of larger fibrils and a relative increase in number of smaller fibrils

• in the tail tendon the fibril size range and average diameter are increased