Phenotypes Associated with This Genotype

Genotype
MGI:5008273

• Allelic Composition: Hipk2^tm1Ejh/Hipk2^tm1Ejh
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:117465 )

• mice exhibit diminished locomotor activity response to amphetamine compared with wild-type mice

abnormal response to novelty ( J:117465 )

• reduced

decreased exploration in new environment ( J:117465 )

• in an open field test

limb grasping ( J:117465 )

dystonia ( J:117465 )

impaired coordination ( J:117465 )

• on a rotarod

abnormal voluntary movement ( J:117465 )

• in four-limb akinesia and negative geotaxis tests, mice exhibit severe retardation in the initiation of voluntary movement compared with wild-type mice

abnormal gait ( J:117465 )

• shuffling with reduced gait width

short stride length ( J:117465 )

nervous system

decreased neuron apoptosis ( J:117465 )

• in dopaminergic neurons at E17.5 and P0

decreased substantia nigra size ( J:117465 )

• reduced in volume

decreased tegmentum size ( J:117465 )

• at P14, mice exhibit a more pronounced deficit in the ventral tegmental area compared with wild-type mice

decreased dopaminergic neuron number ( J:117465 )

• at P0 and throughout adulthood

• in the substantia nigra pars compacta and ventral tegmental area

muscle

dystonia ( J:117465 )

homeostasis/metabolism

decreased dopamine level ( J:117465 )

• in the striatum

cellular

decreased neuron apoptosis ( J:117465 )

• in dopaminergic neurons at E17.5 and P0