Phenotypes Associated with This Genotype

Genotype
MGI:4943295

• Allelic Composition: Cfl1^tm1.1Wit/Cfl1^tm1.1Wit
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125317 )

• rare survivors die by P30

postnatal lethality, incomplete penetrance ( J:125317 )

• nearly all mice die by between P1 and P3

nervous system

seizures ( J:125317 )

• in rare survivors

abnormal neuron differentiation ( J:125317 )

• neuronal progenitors exit the cell cycle prematurely and differentiate

abnormal axon extension ( J:125317 )

• neurite outgrowth is impaired compared to in wild-type mice

premature neuronal precursor differentiation ( J:125317 )

• between E13 and E19, neuronal progenitor cells in the ventricular zone exhibit a migratory defect that prevents them from entering intermediate layers unlike in wild-type mice

• at E18, radial migration of proliferating cells into the cortex is impaired compared to in wild-type mice

• neuronal progenitors fail to reach the medial pallium unlike in wild-type mice

• interkinetic nuclear migration in the ventricular zone is impaired compared to in wild-type mice

abnormal neuronal precursor proliferation ( J:125317 )

• at E14 and E16, mice exhibit impaired cell proliferation of cells in the ventricular zone compared to in wild-type mice

enlarged brain ventricles ( J:125317 )

abnormal cerebral cortex morphology ( J:125317 )

• large parts of layers II, III, and IV are missing compared with wild-type mice

• however, the upper molecular layer I and the inner multiform layer VI are present

abnormal neurite morphology ( J:125317 )

• neurites are shorter than in wild-type cells

behavior/neurological

ataxia ( J:125317 )

• in rare survivors

seizures ( J:125317 )

• in rare survivors

growth/size/body

postnatal growth retardation ( J:125317 )

• in rare survivors

cellular

abnormal neuron differentiation ( J:125317 )

• neuronal progenitors exit the cell cycle prematurely and differentiate

abnormal axon extension ( J:125317 )

• neurite outgrowth is impaired compared to in wild-type mice

premature neuronal precursor differentiation ( J:125317 )

• between E13 and E19, neuronal progenitor cells in the ventricular zone exhibit a migratory defect that prevents them from entering intermediate layers unlike in wild-type mice

• at E18, radial migration of proliferating cells into the cortex is impaired compared to in wild-type mice

• neuronal progenitors fail to reach the medial pallium unlike in wild-type mice

• interkinetic nuclear migration in the ventricular zone is impaired compared to in wild-type mice

abnormal neuronal precursor proliferation ( J:125317 )

• at E14 and E16, mice exhibit impaired cell proliferation of cells in the ventricular zone compared to in wild-type mice