Phenotypes Associated with This Genotype

Genotype
MGI:4943239

• Allelic Composition: Grhl2^m1Nisw/Grhl2^m1Nisw
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:169829 )

• some mice survive to E18.5

lethality throughout fetal growth and development, complete penetrance ( J:169829 )

• Background Sensitivity: some mice survive to E18.5 on a mixed background

craniofacial

abnormal cranium morphology ( J:169829 )

• at E18.5, mice lack components of the top of the skull and midface unlike wild-type mice

• however, mice exhibit normal lower jaw and ventral skull

abnormal midface morphology ( J:169829 )

• at E18.5, mice lack components of the midface unlike wild-type mice

facial cleft ( J:169829 )

• all mice exhibit cleft face or unilateral or bilateral cleft

skeleton

abnormal cranium morphology ( J:169829 )

• at E18.5, mice lack components of the top of the skull and midface unlike wild-type mice

• however, mice exhibit normal lower jaw and ventral skull

split sternum ( J:169829 )

limbs/digits/tail

syndactyly ( J:169829 )

• of soft tissue

interdigital webbing ( J:169829 )

• in some mice

nervous system

open neural tube ( J:169829 )

• at E9.5

• however, neural folds elevate normally

exencephaly ( J:169829 )

• in all mice

embryo

open neural tube ( J:169829 )

• at E9.5

• however, neural folds elevate normally

growth/size/body

abnormal midface morphology ( J:169829 )

• at E18.5, mice lack components of the midface unlike wild-type mice

facial cleft ( J:169829 )

• all mice exhibit cleft face or unilateral or bilateral cleft

abnormal body wall morphology ( J:169829 )

• in 50% of mice

vision/eye

coloboma ( J:169829 )