Phenotypes Associated with This Genotype

Genotype
MGI:4943177

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Tg(Gh1-cre)bKnmn/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating hormone level ( J:169459 )

decreased circulating insulin level ( J:169459 )

• in diphtheria toxin-treated mice when a high-fat diet or a low-fat diet

decreased circulating insulin-like growth factor I level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat or low-fat diet

increased circulating leptin level ( J:169459 )

• in diphtheria toxin-treated mice

decreased circulating growth hormone level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat or low-fat diet

abnormal energy expenditure ( J:169459 )

decreased energy expenditure ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat during the nocturnal phase or when mice are fed a high-fat diet

abnormal gas homeostasis ( J:169459 )

decreased oxygen consumption ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat during the nocturnal phase

increased respiratory quotient ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat

abnormal glucose homeostasis ( J:169459 )

decreased circulating glucose level ( J:169459 )

• in diphtheria toxin-treated mice when fed standard chow

• in diphtheria toxin-treated mice when fed a high-fat diet or a low-fat diet during an insulin tolerance test

impaired glucose tolerance ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

increased insulin sensitivity ( J:169459 )

• in diphtheria toxin-treated mice when fed standard chow, a high-fat diet, or a low-fat diet

decreased liver triglyceride level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

endocrine/exocrine glands

decreased somatotroph cell number ( J:169459 )

• in diphtheria toxin-treated mice

small adenohypophysis ( J:169459 )

• in diphtheria toxin-treated mice

adipose tissue

increased subcutaneous adipose tissue amount ( J:169459 )

• in diphtheria toxin-treated mice

increased total body fat amount ( J:169459 )

• in diphtheria toxin-treated mice fed standard chow or a high fat diet

increased retroperitoneal fat pad weight ( J:169459 )

• in diphtheria toxin-treated mice

growth/size/body

decreased lean body mass ( J:169459 )

• in diphtheria toxin-treated mice

decreased body weight ( J:169459 )

• in diphtheria toxin-treated mice fed a high fat diet

liver/biliary system

decreased liver triglyceride level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

decreased liver weight ( J:169459 )

• in diphtheria toxin-treated mice fed standard chow or a high fat diet

nervous system

decreased somatotroph cell number ( J:169459 )

• in diphtheria toxin-treated mice

small adenohypophysis ( J:169459 )

• in diphtheria toxin-treated mice

behavior/neurological

decreased fluid intake ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat

integument

increased subcutaneous adipose tissue amount ( J:169459 )

• in diphtheria toxin-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
isolated growth hormone deficiency		DOID:0060870		J:169459