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Phenotypes Associated with This Genotype
Genotype
MGI:4839562
cn49
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (54 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:135172 )
• die before P68 with vascular complications

hematopoietic system
abnormal definitive hematopoiesis ( J:135172 )
• 100% of mutants develop myeloproliferative disorder at about P30

cardiovascular system
abnormal blood vessel morphology ( J:135172 )
• mutants exhibit vascular complication

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory