Phenotypes Associated with This Genotype

Genotype
MGI:4839228

cn16

• Allelic Composition: Adam10^tm1Beni/Adam10^tm1Beni; Adam17^tm1.1Srj/Adam17^tm1.1Srj; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:165863 )

• adult mice deficient in both metalloproteinases were rarely obtained (frequency: 2.5%)

hematopoietic system

abnormal platelet physiology ( J:165863 )

• when bone marrow is transplanted into irradiated wild-type mice, platelets treated with a calmodulin inhibitor (W7) or a mitochondrial damage reagent (CCCP) fail to shed GPVI in vitro unlike similarly treated wild-type cells

• however, in vivo shedding is normal

homeostasis/metabolism

abnormal platelet physiology ( J:165863 )

• when bone marrow is transplanted into irradiated wild-type mice, platelets treated with a calmodulin inhibitor (W7) or a mitochondrial damage reagent (CCCP) fail to shed GPVI in vitro unlike similarly treated wild-type cells

• however, in vivo shedding is normal