Phenotypes Associated with This Genotype

Genotype
MGI:4836241

• Allelic Composition: Tg(Pbsn-TAg)15Tvd/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal prostate gland epithelium morphology ( J:103408 )

♂ • increase in proliferation in prostatic luminal epithelial cells

♂ • 5-6-fold increase in apoptosis in prostatic luminal epithelial cells

prostate gland epithelial hyperplasia ( J:103408 )

♂ • prostates exhibit abnormal gland architecture as early as 6 weeks of age showing focal hyperplasias with nuclear atypia

increased prostate gland adenocarcinoma incidence ( J:103408 )

♂ • develop focally invasive well-differentiated adenocarcinomas by 16 weeks of age

♂ • adenocarcinomas do not become grossly invasive within 22 months of observation, however, they do show microinvasion

increased prostate intraepithelial neoplasia incidence ( J:103408 )

♂ • by 12 weeks of age, mutants exhibit traits of murine prostatic intraepithelial neoplasia (mPIN), including epithelial layer stratification, accompanied by hypercellularity of the fibromuscular stromal cell layer

reproductive system

abnormal prostate gland epithelium morphology ( J:103408 )

♂ • increase in proliferation in prostatic luminal epithelial cells

♂ • 5-6-fold increase in apoptosis in prostatic luminal epithelial cells

prostate gland epithelial hyperplasia ( J:103408 )

♂ • prostates exhibit abnormal gland architecture as early as 6 weeks of age showing focal hyperplasias with nuclear atypia

increased prostate gland adenocarcinoma incidence ( J:103408 )

♂ • develop focally invasive well-differentiated adenocarcinomas by 16 weeks of age

♂ • adenocarcinomas do not become grossly invasive within 22 months of observation, however, they do show microinvasion

increased prostate intraepithelial neoplasia incidence ( J:103408 )

♂ • by 12 weeks of age, mutants exhibit traits of murine prostatic intraepithelial neoplasia (mPIN), including epithelial layer stratification, accompanied by hypercellularity of the fibromuscular stromal cell layer

male infertility ( J:103408 )

♂ • aging males exhibit sterility

neoplasm

increased prostate gland adenocarcinoma incidence ( J:103408 )

♂ • develop focally invasive well-differentiated adenocarcinomas by 16 weeks of age

♂ • adenocarcinomas do not become grossly invasive within 22 months of observation, however, they do show microinvasion

increased prostate intraepithelial neoplasia incidence ( J:103408 )

♂ • by 12 weeks of age, mutants exhibit traits of murine prostatic intraepithelial neoplasia (mPIN), including epithelial layer stratification, accompanied by hypercellularity of the fibromuscular stromal cell layer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:103408