Phenotypes Associated with This Genotype

Genotype
MGI:4430223

ht4

• Allelic Composition: Scn8a^Clth/Scn8a⁺
• Genetic Background: involves: BALB/cAnN * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:155726 )

• as early as P25, some mice exhibit episodic periods of extended freezing behavior, piloerection, a hunched posture, and intermittent side-to-side coarse tremors unlike wild-type mice

• however, mice exhibit normal vestibular-dependent behaviors

abnormal pilomotor reflex ( J:155726 )

abnormal pinna reflex ( J:155726 )

• Peyer's reflex is mild or absent unlike in wild-type mice

absent pinna reflex ( J:155726 )

• in some mice

decreased startle reflex ( J:155726 )

• at 5 weeks of age, startle reflex is mild or absent compared to in wild-type mice

• impaired startle reflex worsens with age

tremors ( J:155726 )

• mice exhibit episodic tremors that increase in frequency and severity with age unlike wild-type mice

hunched posture ( J:155726 )

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:155726 )

N • outer, middle, and inner ears are morphologically normal

increased or absent threshold for auditory brainstem response ( J:155726 )

• at 8 kHz

impaired hearing ( J:155726 )

• mild semi-dominant

growth/size/body

decreased body weight ( J:155726 )

• as early as 18 weeks