Phenotypes Associated with This Genotype

Genotype
MGI:4429452

• Allelic Composition: Fgfr4^tm1Axul/Fgfr4^tm1Axul; Tg(WapTgfa)215Bri/0
• Genetic Background: B6.Cg-Fgfr4^tm1Axul Tg(WapTgfa)215Bri

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:156750 )

• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone

• more and larger tumors in 8-month-old female compared to Tg alone

• tumors are visible significantly earlier compared to Tg alone

increased metastatic potential ( J:156750 )

• a significantly earlier incidence of lung metastases

• at 8-months of age there are more small and large lung metastases

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:156750 )

• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone

• more and larger tumors in 8-month-old female compared to Tg alone

• tumors are visible significantly earlier compared to Tg alone

integument

increased mammary adenocarcinoma incidence ( J:156750 )

• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone

• more and larger tumors in 8-month-old female compared to Tg alone

• tumors are visible significantly earlier compared to Tg alone

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:156750