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Fgfr4tm1Axul
Targeted Allele Detail
Summary
Symbol: Fgfr4tm1Axul
Name: fibroblast growth factor receptor 4; targeted mutation 1, Axel Ullrich
MGI ID: MGI:4429449
Synonyms: FGFR4Arg385, FGFR4-R385
Gene: Fgfr4  Location: Chr13:55300631-55316572 bp, + strand  Genetic Position: Chr13, 29.8 cM
Alliance: Fgfr4tm1Axul page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156750
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA loxP flanked Neo cassette was inserted into intron 10 and a single nucleotide substitution that resulted in an amino acid substitution of Glycine 385 to Arginine (G385R) was inserted into exon 8 by homologous recombination. (J:156750)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Fgfr4tm1Axul
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr4 Mutation:  39 strains or lines available
References
Original:  J:156750 Seitzer N, et al., A single nucleotide change in the mouse genome accelerates breast cancer progression. Cancer Res. 2010 Jan 15;70(2):802-12
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory