Phenotypes Associated with This Genotype

Genotype
MGI:4417905

cn7

• Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf; Junb^tm3Wag/Junb^tm3Wag; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:155575 )

N • mice exhibit normal lifespan unlike Junb^tm3Wag/Junb^tm3Wag Tg(KRT5-cre)1Tak mice

immune system

immune system phenotype ( J:155575 )

N • mice exhibit a rescue of the systemic lupus erythematosus associated phenotypes observed in Junb^tm3Wag/Junb^tm3Wag Tg(KRT5-cre)1Tak mice including normal lymph node architecture, plasma cell count, and antinuclear autoantibodies

skin inflammation ( J:155575 )

• mild

renal/urinary system

renal/urinary system phenotype ( J:155575 )

N • mice exhibit a rescue of the lupus associated kidney phenotypes observed in Junb^tm3Wag/Junb^tm3Wag Tg(KRT5-cre)1Tak mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:155575 )

N • ce exhibit normal urine albumin levels unlike in Junb^tm3Wag/Junb^tm3Wag Tg(KRT5-cre)1Tak mice

integument

integument phenotype ( J:155575 )

N • mice exhibit a rescue of the lupus associated skin phenotypes observed in Junb^tm3Wag/Junb^tm3Wag Tg(KRT5-cre)1Tak mice

skin inflammation ( J:155575 )

• mild

hyperkeratosis ( J:155575 )

• mild

thick skin ( J:155575 )

• milder than in Junb^tm3Wag/Junb^tm3Wag Tg(KRT5-cre)1Tak mice