Phenotypes Associated with This Genotype

Genotype
MGI:4410366

cn3

• Allelic Composition: Chd7^Whi/Chd7⁺
• Genetic Background: B6.C3Fe-Chd7^Whi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Malformations of the semicircular canals in Chd7^Whi/Chd7⁺, Tbx1^tm1Bld/Tbx1⁺, and Chd7^Whi/Chd7⁺ Tbx1^tm1Bld/Tbx1⁺ mice

hearing/vestibular/ear

abnormal lateral semicircular canal morphology ( J:154590 )

• 20% of mice exhibit lateral canal truncations unlike wild-type mice

• 67% of mice possess an ampulla only unlike wild-type mice

absent lateral semicircular canal ( J:154590 )

• in 13% of mice

abnormal posterior semicircular canal morphology ( J:154590 )

• 93% mice exhibit posterior canal truncations unlike wild-type mice

• 7% of mice exhibit posterior canal fused to the crus commune unlike wild-type mice