Phenotypes for Ahi1 Lrp6 MGI:4367782 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ahi1^tm1Jgg/Ahi1⁺ Lrp6^Gt(Ex187)Byg/Lrp6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1^tm1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Lrp6^Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney cyst ( J:154321 )

• at later stages

small kidney ( J:154321 )

abnormal renal tubule morphology ( J:154321 )

• tubule abnormalities are consistent with nephronophthisis

dilated renal tubule ( J:154321 )

• at later stages

homeostasis/metabolism

increased circulating creatinine level ( J:154321 )

• in one mouse

growth/size/body

kidney cyst ( J:154321 )

• at later stages

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nephronophthisis		DOID:12712	OMIM:PS256100	J:154321

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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