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Phenotypes Associated with This Genotype
Genotype
MGI:4366922
Allelic
Composition		 Pold1tm1.1Bdp/Pold1tm1.1Bdp
Poletm1.1Bdp/Poletm1.1Bdp
Genetic
Background		 B6.129-Poletm1.1Bdp Pold1tm1.1Bdp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1tm1.1Bdp mutation (0 available); any Pold1 mutation (60 available)
Poletm1.1Bdp mutation (0 available); any Pole mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:153684 )
• mice die before 6 months

neoplasm
increased T cell derived lymphoma incidence ( J:153684 )
• in 82% of mice unlike in wild-type mice
increased skin tumor incidence ( J:153684 )
• 6% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

integument
increased skin tumor incidence ( J:153684 )
• 6% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:153684 )
• in 82% of mice unlike in wild-type mice

immune system
increased T cell derived lymphoma incidence ( J:153684 )
• in 82% of mice unlike in wild-type mice

hematopoietic system
increased T cell derived lymphoma incidence ( J:153684 )
• in 82% of mice unlike in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory