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Phenotypes Associated with This Genotype
Genotype
MGI:4365971
hm1
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
B6.129S7-Ifngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (18 available); any Ifng mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

mortality/aging
• sudden death occurs 5 to 7 weeks after infection with Leishmania major (J:18801)
• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls (J:110826)
• higher mortality is seen following infection with JHMV compared to wild-type controls
• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background

neoplasm
• Background Sensitivity: 50% of mice on a congenic C57BL/5 background develop disseminated lymphomas compared to 0% of mice on a congenic BALB/c background
• most lymphomas are diffuse large cell lymphomas
• in a few mice
• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background

immune system
• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection
• immature B cells fail to be excluded from the lymph nodes
• after infection with Leishmania major
• after infection with Leishmania major (J:18801)
• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls (J:112048)
• after infection with Leishmania major
• after infection with Leishmania major
• significant increase in the numbers of immature B cells in the lymph nodes
• after infection with Leishmania major the number of lymphocytes producing IL4 increases unlike in control mice where the number of lymphocytes producing IFNG increases (J:18801)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL10 in response to JHMV antigen compared to cells from similarly infected wild-type mice
• cervical lymph node cells from JHMV infected mice secrete more IL2 in response to JHMV antigen compared to cells from similarly infected wild-type mice
• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL5 in response to JHMV antigen compared to cells from similarly infected wild-type mice
• after infection with Leishmania major mice display minimal Th1 type responses and increased Th2 type responses (J:18801)
• after infection with Leishmania major levels of IgG1 and IgE are increased while levels of IgG2a and IgG3 remain low (J:18801)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• develop progressive infection characterized by large lesions at the site of inoculation and sudden death 5 to 7 weeks after infection with Leishmania major
• numbers of parasites present in the footpads are substantially increased compared to wild-type and heterozygous controls
• sudden death occurs 5 to 7 weeks after infection with Leishmania major (J:18801)
• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls (J:110826)
• following infection with the JHM strain of mouse hepatitis virus (JHMV) mice display a slower clinical recovery and higher viral titers in the central nervous system compared to wild-type controls
• however, no differences are found in JHMV specific cytotoxic T lymphocyte activity
• at 14 days post infection with JHMV a 10 fold increase in the number of viral antigen positive cells is detected in the brain with most of the infected cells being oligodendrocytes
• higher mortality is seen following infection with JHMV compared to wild-type controls
• after immunosuppressive treatment (anti-CD4 and anti-CD8 mAbs) allografts (BALB/c, H2-Ab1bm12 continue to display myocardial rejection at week 12 but do not display graft arterial disease, in contrast wild-type mice at week 12 display low levels of rejection but develop coronary arteriopathy

hematopoietic system
• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection
• immature B cells fail to be excluded from the lymph nodes
• after infection with Leishmania major
• after infection with Leishmania major (J:18801)
• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls (J:112048)
• after infection with Leishmania major
• after infection with Leishmania major


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory