Phenotypes Associated with This Genotype

Genotype
MGI:4365781

cn1

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt; Osr2^tm5(cre)Jian/Osr2⁺
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:153554 )

craniofacial

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

cleft palate ( J:153554 )

embryo

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

digestive/alimentary system

cleft palate ( J:153554 )

growth/size/body

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

cleft palate ( J:153554 )

skeleton

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal