Phenotypes for Npc1 Nr1h2 MGI:4359169 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Npc1^m1N/Npc1^m1N Nr1h2^tm1Djm/Nr1h2^tm1Djm
Genetic Background	involves: 129S6/SvEvTac * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npc1^m1N mutation (3 available); any Npc1 mutation (73 available)
Nr1h2^tm1Djm mutation (3 available); any Nr1h2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:130969 )

• mice die between 60 and 90 days of age from neurodegenerative disease, which is significantly faster than Npc1 mutants on a wild-type background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Niemann-Pick disease		DOID:14504		J:130969

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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