Phenotypes Associated with This Genotype

Genotype
MGI:4358706

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Lcat^tm1Hgc/Lcat^tm1Hgc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:75567 )

N • unlike Lcat single mutants, the free cholesterol/esterfied cholesterol ratio is not significantly different from controls

abnormal circulating protein level ( J:75567 )

• increase in APOB-48

abnormal lipid homeostasis ( J:75567 )

• about a 2 fold increase in all plasma lipid constituents compared to mice homozygous null for Lcat and Ldlr

• compared to Apoe single mutants the percentage of long chain PUFA in the total APOB lipoprotein cholesterol ester fraction is decreased

abnormal cholesterol homeostasis ( J:75567 )

• compared to Apoe single mutants cholesteryl stearate and oleate levels are increased 46% and 22%, respectively

• there is a 1.6 fold increase in the ratio of saturated + monounsaturated/polyunsaturated cholesterol ester fatty acid species compared to Apoe single mutants