Lcat^tm1Hgc
Targeted Allele Detail

Summary

• Symbol: Lcat^tm1Hgc
• Name: lecithin cholesterol acyltransferase; targeted mutation 1, Edward M Rubin
• MGI ID: MGI:2180695
• Synonyms: Lcat (-), LCAT^-
• Gene: Lcat Location: Chr8:106666183-106670014 bp, - strand Genetic Position: Chr8, 53.06 cM
• Alliance: Lcat^tm1Hgc page

Plasma lipoprotein fractions of Lcat^tm1Hgc/Lcat^tm1Hgc mice contain smaller VLDL particles and complex HDL particles

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance cassette via homologous recombination. Exogenous substrate assay of plasma from homozygous mutant animals showed no detectable enzyme activity. (J:41208)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcat Mutation: 24 strains or lines available

References

• Original: J:41208 Ng DS, et al., Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I. J Biol Chem. 1997 Jun 20;272(25):15777-81
• All: 23 reference(s)