Phenotypes for 7630403G23Rik Gt(ROSA)26Sor MGI:3851906 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm2(SNCA119)Djmo}/Gt(ROSA)26Sor^{tm2(SNCA119)Djmo} 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23Rik^{Tg(Th-cre)1Tmd} mutation (1 available); any 7630403G23Rik mutation (3 available)
Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating noradrenaline level ( J:150777 )

• increased levels of norepinephrine observed in striatum in 10-11 month old mice

decreased dopamine level ( J:150777 )

• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice

increased serotonin level ( J:150777 )

• increased levels of 5-HT observed in prefrontal cortex in 10-11 month old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:150777

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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