Phenotypes Associated with This Genotype

Genotype
MGI:3850819

• Allelic Composition: Ts(17¹⁶)65Dn/0
• Genetic Background: B6EiC3Sn a/A-Ts(17¹⁶)65Dn/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor growth/size ( J:150286 )

• transplanted Lewis lung and B16F10 tumor cells exhibit growth suppression with reduced microvessel density compared to tumor cells transplanted into wild-type mice

behavior/neurological

abnormal learning/memory/conditioning ( J:153579 )

• in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test

impaired contextual conditioning behavior ( J:153579 )

impaired cued conditioning behavior ( J:153579 )

abnormal spatial learning ( J:153579 , J:170195 )

• physical exercise improves performance of 12-13 month old mutants, but not controls, in the acquisition of the Morris water maze (J:170195)

• however, physical exercise has no effect on anxiety or depression behaviors in mutants (J:170195)

decreased grip strength ( J:153579 )

• output of a grip strength meter shows reduced grip force relative to controls

hyperactivity ( J:153579 )

• although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls

increased vertical activity ( J:153579 )

• significantly increased dark cycle rearing

increased stereotypic behavior ( J:153579 )

• significantly increased dark cycle horizontal and vertical stereotypic activity

growth/size/body

decreased body weight ( J:153579 , J:170195 )

decreased body length ( J:153579 )

• the length from the nost to the tip of the tail and the length from the nose to the base of the tail are shorter than in background controls

nervous system

abnormal hippocampus morphology ( J:170195 )

• mutants exhibit reduced cell proliferation and apoptosis in the hippocampus

• mutants exhibit a smaller subgranular zone

• exercise has no effect on the size of subgranular zone

abnormal dentate gyrus morphology ( J:170195 )

• mutants exhibit a smaller dentate gyrus volume

• exercise has no effect on the size of dentate gyrus volume

abnormal hippocampus granule cell layer ( J:170195 )

• mutants exhibit reduced number of granule cells

• exercise has no effect on the number of granule cells

abnormal nervous system development ( J:170195 )

• hippocampal neurogenesis is reduced

• exercise has no effect on hippocampal neurogenesis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:170195