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Phenotypes Associated with This Genotype
B6EiC3Sn a/A-Ts(1716)65Dn/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• transplanted Lewis lung and B16F10 tumor cells exhibit growth suppression with reduced microvessel density compared to tumor cells transplanted into wild-type mice

• in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test
• physical exercise improves performance of 12-13 month old mutants, but not controls, in the acquisition of the Morris water maze (J:170195)
• however, physical exercise has no effect on anxiety or depression behaviors in mutants (J:170195)
• output of a grip strength meter shows reduced grip force relative to controls
• although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls
• significantly increased dark cycle rearing
• significantly increased dark cycle horizontal and vertical stereotypic activity

• the length from the nost to the tip of the tail and the length from the nose to the base of the tail are shorter than in background controls

nervous system
• mutants exhibit reduced cell proliferation and apoptosis in the hippocampus
• mutants exhibit a smaller subgranular zone
• exercise has no effect on the size of subgranular zone
• mutants exhibit a smaller dentate gyrus volume
• exercise has no effect on the size of dentate gyrus volume
• mutants exhibit reduced number of granule cells
• exercise has no effect on the number of granule cells
• hippocampal neurogenesis is reduced
• exercise has no effect on hippocampal neurogenesis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory