Phenotypes Associated with This Genotype

Genotype
MGI:3848461

hm1

• Allelic Composition: Mlh1^tm1Lisk/Mlh1^tm1Lisk
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:75745 )

• survival is 65% at 9 months

preweaning lethality, incomplete penetrance ( J:75745 )

• fewer than expected mice are observed (no time of death given)

neoplasm

increased intestinal adenocarcinoma incidence ( J:75745 )

• by 9 months, 83% of mice develop adenomas or adenocarcinomas in the intestinal tract

increased intestinal adenoma incidence ( J:75745 )

• by 9 months, 83% of mice develop adenomas or adenocarcinomas in the intestinal tract

increased skin tumor incidence ( J:75745 )

• in one mouse

increased lymphoma incidence ( J:75745 )

• in 21% of mice by 9 months of age

increased uterus tumor incidence ( J:75745 )

♀ • one mouse developed a tumor of the uterine epithelium

integument

increased skin tumor incidence ( J:75745 )

• in one mouse

reproductive system

increased uterus tumor incidence ( J:75745 )

♀ • one mouse developed a tumor of the uterine epithelium

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:75745 )

• by 9 months, 83% of mice develop adenomas or adenocarcinomas in the intestinal tract

increased intestinal adenoma incidence ( J:75745 )

• by 9 months, 83% of mice develop adenomas or adenocarcinomas in the intestinal tract