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Phenotypes Associated with This Genotype
Genotype
MGI:3848460
cx4
Allelic
Composition		 Dnmt1tm1Jae/Dnmt1tm1Pwl
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (112 available)
Dnmt1tm1Pwl mutation (0 available); any Dnmt1 mutation (112 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:75745 )
• mice exhibit poorer survival than in Mlh1tm1Lisk homozygotes

neoplasm
neoplasm ( J:75745 )
N
• no mice develop intestinal tumors
increased lymphoma incidence ( J:75745 )
• 90% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory