Phenotypes Associated with This Genotype

Genotype
MGI:3848458

cx5

• Allelic Composition: Dnmt1^tm1Pwl/Dnmt1⁺; Mlh1^tm1Lisk/Mlh1^tm1Lisk
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:75745 )

• mice exhibit reduced survival compared with wild-type mice

neoplasm

increased intestinal adenocarcinoma incidence ( J:75745 )

• 61% of mice develop intestinal tumors

increased intestinal adenoma incidence ( J:75745 )

• 61% of mice develop intestinal tumors

increased lymphoma incidence ( J:75745 )

• 29% of mice develop lymphomas

• mice develop lymphomas at an earlier age than in Mlh1^tm1Lisk homozygotes

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:75745 )

• 61% of mice develop intestinal tumors

increased intestinal adenoma incidence ( J:75745 )

• 61% of mice develop intestinal tumors