Phenotypes Associated with This Genotype

Genotype
MGI:3835117

• Allelic Composition: Tg(WapTAg)3Knw/0
• Genetic Background: C57BL/6J-Tg(WapTAg)3Knw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:53175 )

• mice are sacrificed due to osteosarcomas that develop at 5.5 to 6 months of age

neoplasm

increased adenocarcinoma incidence ( J:53175 )

• mice develop renal adenocarcinomas that are limited to the pelvis and papilla

increased mammary adenocarcinoma incidence ( J:53175 )

• mammary adenocarcinoma is found in multiparous females but not males or virgin females, with an average latency of 6 months

increased sarcoma incidence ( J:53175 )

• in males and virgin females, but not multiparous females, poorly differentiated soft cell sarcomas are observed frequently, usually on the trunk or extremities, with average latency of 13 months

increased osteosarcoma incidence ( J:53175 )

• osteosaromas that develop on the floor of the skull from the os petrosum compress the brain to varying degrees

behavior/neurological

ataxia ( J:53175 )

• at 6 months

abnormal nursing ( J:53175 )

♀ • female mice fail to suckle their young

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:53175 )

• mammary adenocarcinoma is found in multiparous females but not males or virgin females, with an average latency of 6 months

mammary gland hyperplasia ( J:53175 )

♀ • in multiparous females

integument

increased mammary adenocarcinoma incidence ( J:53175 )

• mammary adenocarcinoma is found in multiparous females but not males or virgin females, with an average latency of 6 months

mammary gland hyperplasia ( J:53175 )

♀ • in multiparous females

skeleton

increased osteosarcoma incidence ( J:53175 )

• osteosaromas that develop on the floor of the skull from the os petrosum compress the brain to varying degrees

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:53175