Phenotypes Associated with This Genotype

Genotype
MGI:3833999

• Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Thymus abnormalities in Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}, Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} and Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{Gt(OST58278)Lex} mice

immune system

decreased T cell number ( J:145159 )

• mice have fewer circulating T cells than in Sgpl1^{tm1(SGPL1)Lex} homozygotes

abnormal osteoclast morphology ( J:145159 )

• a small number of distended osteoclasts are present at the growth plate

• however, mice exhibit normal trabecular bone in the meptaphysis and diaphysis of the long bones

abnormal immune system organ morphology ( J:145159 )

• mice exhibit the same defects in lymphoid tissue morphology as in Sgpl1^{tm1(SGPL1)Lex} homozygotes

• however, mice do not exhibit defects in non-lymphoid tissues

thymus cortex hypoplasia ( J:145159 )

• the number of lymphocytes in the thymic cortex is mildly decreased compared to in wild-type mice

thymus medulla hyperplasia ( J:145159 )

• the number of lymphocytes in the medulla is mildly increased compared to in wild-type mice

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:145159 )

• mice exhibit multifocal minimal vacuolization and degeneration of the urinary bladder urothelium unlike in wild-type mice

skeleton

abnormal osteoclast morphology ( J:145159 )

• a small number of distended osteoclasts are present at the growth plate

• however, mice exhibit normal trabecular bone in the meptaphysis and diaphysis of the long bones

cardiovascular system

cardiovascular system phenotype ( J:145159 )

N • heart morphology is normal

respiratory system

respiratory system phenotype ( J:145159 )

N • lung morphology is normal

hematopoietic system

thymus cortex hypoplasia ( J:145159 )

• the number of lymphocytes in the thymic cortex is mildly decreased compared to in wild-type mice

thymus medulla hyperplasia ( J:145159 )

• the number of lymphocytes in the medulla is mildly increased compared to in wild-type mice

decreased T cell number ( J:145159 )

• mice have fewer circulating T cells than in Sgpl1^{tm1(SGPL1)Lex} homozygotes

abnormal osteoclast morphology ( J:145159 )

• a small number of distended osteoclasts are present at the growth plate

• however, mice exhibit normal trabecular bone in the meptaphysis and diaphysis of the long bones

endocrine/exocrine glands

thymus cortex hypoplasia ( J:145159 )

• the number of lymphocytes in the thymic cortex is mildly decreased compared to in wild-type mice

thymus medulla hyperplasia ( J:145159 )

• the number of lymphocytes in the medulla is mildly increased compared to in wild-type mice