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Phenotypes Associated with This Genotype
Genotype
MGI:3831883
cx10
Allelic
Composition
Pot1btm1.1Schg/Pot1btm1.1Schg
Terctm1Rdp/Terctm1Rdp
Genetic
Background
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pot1btm1.1Schg mutation (0 available); any Pot1b mutation (39 available)
Terctm1Rdp mutation (4 available); any Terc mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice but one mouse born alive died within days of birth
• the single exception died by P13, all additional phenotype data is for this single mouse

reproductive system
• near complete absence of germ cells representing all stages of spermatogenesis
• near complete absence of all stages of spermatogenesis

hematopoietic system
• striking absence of bone marrow cells
• acute bone marrow failure
• severe

digestive/alimentary system
• increased intestinal apoptosis

immune system

cellular
• near complete absence of germ cells representing all stages of spermatogenesis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/24/2026
MGI 6.24
The Jackson Laboratory