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Phenotypes Associated with This Genotype
Genotype
MGI:3829605
Allelic
Composition		 Sohlh2tm1Miya/Sohlh2tm1Miya
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sohlh2tm1Miya mutation (1 available); any Sohlh2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatocyte morphology ( J:143535 )
• during adult spermatogenesis, almost no spermatocytes are observed unlike in wild-type mice
abnormal spermatogonia morphology ( J:143535 )
• while undifferentiated spermatogonia appear normal, differentiated cells degenerate
absent ovarian follicles ( J:143535 )
• mice lack follicles and their development cannot be initiated by treatment with gonadotrophin
impaired ovarian folliculogenesis ( J:143535 )
• at P3, oocytes and follicles are smaller and asymmetrical compared to in wild-type mice
• at P7, most follicles degenerate and surrounding cells remain flat unlike in wild-type mice
• follicular development is defective in the primordial-to-primary follicle formation
female infertility ( J:143535 )
• despite normal sexual behavior, mice are sterile
male infertility ( J:143535 )
• despite normal sexual behavior, mice are sterile

endocrine/exocrine glands
absent ovarian follicles ( J:143535 )
• mice lack follicles and their development cannot be initiated by treatment with gonadotrophin
impaired ovarian folliculogenesis ( J:143535 )
• at P3, oocytes and follicles are smaller and asymmetrical compared to in wild-type mice
• at P7, most follicles degenerate and surrounding cells remain flat unlike in wild-type mice
• follicular development is defective in the primordial-to-primary follicle formation

cellular
abnormal spermatocyte morphology ( J:143535 )
• during adult spermatogenesis, almost no spermatocytes are observed unlike in wild-type mice
abnormal spermatogonia morphology ( J:143535 )
• while undifferentiated spermatogonia appear normal, differentiated cells degenerate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory