Phenotypes Associated with This Genotype

Genotype
MGI:3815300

• Allelic Composition: Tg(Pax8-rtTA2S*M2)1Koes/0; Tg(tetO-MYC)36aBop/0
• Genetic Background: involves: C57BL/6 * DBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

kidney cyst ( J:140925 )

• following induction with doxycycline, mice develop glomerular cysts

polycystic kidney ( J:140925 )

• following induction with doxycycline, mice develop multiple renal cysts in all renal tubular compartments

increased renal carcinoma incidence ( J:140925 )

• following induction with doxycycline

kidney failure ( J:140925 )

• 3 to 4 months following induction with doxycycline

neoplasm

increased adenoma incidence ( J:140925 )

• following induction with doxycycline, mice develop renal adenomas

increased renal carcinoma incidence ( J:140925 )

• following induction with doxycycline

growth/size/body

kidney cyst ( J:140925 )

• following induction with doxycycline, mice develop glomerular cysts

polycystic kidney ( J:140925 )

• following induction with doxycycline, mice develop multiple renal cysts in all renal tubular compartments

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cystic kidney disease		DOID:2975		J:140925