Phenotypes Associated with This Genotype

Genotype
MGI:3814539

ht2

• Allelic Composition: Trp53^tm1Ldo/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:73757 )

• old mice treated with Avertin or 5-fluorouracil exhibit increased mortality compared to similarly treated wild-type mice

premature death ( J:73757 )

• median lifespan is 96 weeks compared to 118 weeks for wild-type mice

premature aging ( J:73757 )

• mice exhibit some phenotypes associated with premature ageing

• however, mice do not exhibit liver pathologies, hair graying, alopecia, atrophy of intestinal villi, skin ulcerations, amyloid depositions, brain atrophy, joint disease or cataracts

respiratory system

increased lung adenoma incidence ( J:73757 )

• one mouse develops a lung adenoma and another a well-differentiated bronchio-alveolar lung adenocarcinoma

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:73757 )

• following treatment with 5-fluorouracil, mice that survive fail to exhibit a robust recovery as do wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:73757 )

• old mice treated with Avertin or 5-fluorouracil exhibit increased mortality compared to similarly treated wild-type mice

delayed wound healing ( J:73757 )

• in old mice

neoplasm

increased lung adenoma incidence ( J:73757 )

• one mouse develops a lung adenoma and another a well-differentiated bronchio-alveolar lung adenocarcinoma

decreased tumor incidence ( J:73757 )

• mice do not develop any life-threatening tumors over the course of their lifespan compared to 45% of wild-type mice

skeleton

lordokyphosis ( J:73757 )

• by 18 months of age, mice exhibit lordokyphosis

decreased bone mineral density ( J:73757 )

• at 24 months of age

muscle

decreased skeletal muscle mass ( J:73757 )

• at 24 months of age, mean quadriceps mass is 2.5-fold lower than in wild-type mice

muscular atrophy ( J:73757 )

• in older mice

reproductive system

decreased testis weight ( J:73757 )

♂ • at 24 months of age

testis hypoplasia ( J:73757 )

♂ • at 24 months of age

renal/urinary system

decreased kidney weight ( J:73757 )

• at 24 months of age

renal hypoplasia ( J:73757 )

• at 24 months of age

liver/biliary system

decreased liver weight ( J:73757 )

• at 24 months of age

liver hypoplasia ( J:73757 )

• at 24 months of age

immune system

decreased spleen weight ( J:73757 )

• at 24 months of age

spleen hypoplasia ( J:73757 )

• at 24 months of age

growth/size/body

weight loss ( J:73757 )

• by 18 months of age

behavior/neurological

lethargy ( J:73757 )

• at 24 months of age

cellular

abnormal cell physiology ( J:73757 )

• mouse embryonic fibroblasts are 2 to 4 fold more resistant to transformation than wild-type cells

endocrine/exocrine glands

decreased testis weight ( J:73757 )

♂ • at 24 months of age

testis hypoplasia ( J:73757 )

♂ • at 24 months of age

hematopoietic system

decreased spleen weight ( J:73757 )

• at 24 months of age

spleen hypoplasia ( J:73757 )

• at 24 months of age

adipose tissue

decreased subcutaneous adipose tissue amount ( J:73757 )

• at 24 months of age, mice display reduced adipose deposition compared to wild-type mice

integument

decreased subcutaneous adipose tissue amount ( J:73757 )

• at 24 months of age, mice display reduced adipose deposition compared to wild-type mice

sparse hair ( J:73757 )

delayed hair regrowth ( J:73757 )

• by 22 to 24 months of age, no hair growth is observed

thin dermal layer ( J:73757 )

• at 24 months of age