Analysis Tools
renal/urinary system
| N |
• no abnormalities are found in the kidney
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reproductive system
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• the few mature sperm found in the cauda epididymis showed morphological abnormalities, with less than 0.5% of total sperm being both motile and viable
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• the flagellar membrane of the rare surviving spermatozoa found in the epididymides are usually ruptured, with the electron-dense microtubules of flagellar axonema dispersed and/or disorganized
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• sperm counts in the testis and the cauda epididymis are significantly reduced by greater than 5-fold and greater than 20-fold, respectively
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• there is a greater than 20-fold reduction in the number of viable sperm found in the cauda epididymis
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• testes weight is significantly lower than controls (80 mg vs. 94 mg in wild-type males)
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• morphological abnormalities are first observed in the elongating spermatids of stages VIII-X
• many of the spermatids prematurely detach from Sertoli cells and degenerate before sloughing off into the lumen
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• male mice are not capable of siring offspring
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endocrine/exocrine glands
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• testes weight is significantly lower than controls (80 mg vs. 94 mg in wild-type males)
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cellular
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• the few mature sperm found in the cauda epididymis showed morphological abnormalities, with less than 0.5% of total sperm being both motile and viable
|
|
|
• the flagellar membrane of the rare surviving spermatozoa found in the epididymides are usually ruptured, with the electron-dense microtubules of flagellar axonema dispersed and/or disorganized
|
|
|
• sperm counts in the testis and the cauda epididymis are significantly reduced by greater than 5-fold and greater than 20-fold, respectively
|
|
|
• there is a greater than 20-fold reduction in the number of viable sperm found in the cauda epididymis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | nephronophthisis 1 | DOID:0111112 |
OMIM:256100 |
J:140205 |
