Phenotypes Associated with This Genotype

Genotype
MGI:3766122

• Allelic Composition: Timo/Timo
• Genetic Background: either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:127183 )

• by 67 weeks of age the mortality rate is about 15% in both males and females compared to 0% in heterozygous and non-transgenic mice

growth/size/body

increased lean body mass ( J:127183 )

obese ( J:127183 )

• significant increase in body weight by 6 to 7 weeks of age

• females and males are 119 and 37% heavier than age-matched non-transgenic controls by 69 weeks of age

increased body length ( J:127183 )

• at 24 weeks of age, mean lengths of female and male mice are increased by about 11 and 7%, respectively

adipose tissue

increased total body fat amount ( J:127183 )

• increase in both total amount and percent of body fat

abnormal fat pad morphology ( J:127183 )

increased mesenteric fat pad weight ( J:127183 )

increased renal fat pad weight ( J:127183 )

increased uterine fat pad weight ( J:127183 )

increased percent body fat/body weight ( J:127183 )

• increase in both total amount and percent of body fat

homeostasis/metabolism

increased circulating leptin level ( J:127183 )

• increased about 10-fold compared to non-transgenic controls

increased circulating cholesterol level ( J:127183 )

• increased by 95% compared to non-transgenic controls

increased circulating LDL cholesterol level ( J:127183 )

• elevation in the LDL but not HDL, serum cholesterol levels

abnormal glucose homeostasis ( J:127183 )

increased circulating glucose level ( J:127183 )

• develops by 9 weeks of age

increased circulating insulin level ( J:127183 )

• in mice older than 8 weeks

impaired glucose tolerance ( J:127183 )

insulin resistance ( J:127183 )

• detected at 6 weeks of age prior to onset of obesity and in mice over 8 weeks of age

behavior/neurological

polyphagia ( J:127183 )

• mice consume 57% more food than non-transgenic controls

• however, no change in energy expenditure is detected

increased aggression towards mice ( J:127183 )

• in a resident-intruder assay latencies to first biting attacks are shorter and duration of biting attacks are longer compared to non-transgenic controls

liver/biliary system

hepatic steatosis ( J:127183 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:127183
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:127183