Phenotypes Associated with This Genotype

Genotype
MGI:3765918

• Allelic Composition: Actr3^{Gt(A009F03)Vau}/Actr3^{Gt(A009F03)Vau}
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:127731 )

• no mice are present by E4.5 and only 50% of expected embryos are present at E3.5

embryo

abnormal preimplantation embryo development ( J:127731 )

embryonic growth arrest ( J:127731 )

• at E3.5, 36 of 85 embryos exhibit developmental arrest and all embryos fail to develop in culture compared to only 30% of wild-type embryos

abnormal blastocyst morphology ( J:127731 )

• in culture blastocysts fail to attach to a gelatinized substrate and do not form outgrowths of trophoblast-like cells unlike wild-type cells