Actr3^{Gt(A009F03)Vau}
Gene trapped Allele Detail

Summary

• Symbol: Actr3^{Gt(A009F03)Vau}
• Name: ARP3 actin-related protein 3; gene trap mutation A009F03, Franz Vauti
• MGI ID: MGI:3765916
• Synonyms: Actr3^tm1Vau, Arp3^GT
• Gene: Actr3 Location: Chr1:125320642-125363464 bp, - strand Genetic Position: Chr1, 54.7 cM, cytoband E3
• Alliance: Actr3^{Gt(A009F03)Vau} page

Mutation origin

• Mutant Cell Line: A009F03
• Germline Transmission: Earliest citation of germline transmission: J:127731
• Parent Cell Line: C4R8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector Type: gene trap
• Mutation details: The PT1betageo gene trap was inserted was inserted into the first intron creating a fusion gene with 206 nucleotides from exon 1 and the lacZ gene. Western blot analysis confirmed reduced protein expression in heterozygote brain, heart, kidney and liver. (J:127731)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Actr3 Mutation: 20 strains or lines available

References

• Original: J:127731 Vauti F, et al., Arp3 is required during preimplantation development of the mouse embryo. FEBS Lett. 2007 Dec 11;581(29):5691-7
• All: 1 reference(s)