Phenotypes Associated with This Genotype

Genotype
MGI:3758053

• Allelic Composition: Raf1^tm1Zim/Raf1^tm1Zim
• Genetic Background: involves: 129/Sv * 129T2/SvEms

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:50696 )

• Background Sensitivity: 95% die between E10.5 and E12.5, earlier than on a mixed CD-1 background

growth/size/body

decreased embryo size ( J:50696 )

embryo

embryonic growth arrest ( J:50696 )

• developmental arrest at E10.5, particularly in the posterior region, which often fails to complete axial rotation

decreased embryo size ( J:50696 )

abnormal neural tube morphology ( J:50696 )

• irregular folding of the neural tube

cardiovascular system

distended pericardium ( J:50696 )

• distended pericardium

nervous system

abnormal neural tube morphology ( J:50696 )

• irregular folding of the neural tube